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    Mus musculus
    Len Zon | 09/11/2014 - 11:30
    Transcription Factor Binding (ChIP-Seq)
    Illumina Genome Analyzer II
    Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration . This represents the Mouse ChIP-seq portion of this dataset.
    Homo sapiens
    Len Zon | 09/11/2014 - 11:30
    Transcription Factor Binding (ChIP-Seq)
    Illumina Genome Analyzer II
    Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. This represents the human CD34+ ChIP-seq portion of this dataset.
    Homo sapiens
    Len Zon | 09/11/2014 - 11:30
    Transcription Factor Binding (ChIP-Seq)
    Illumina Genome Analyzer II
    Lineage regulators direct BMP and Wnt pathways to cell-specific programs during differentiation and regeneration. This represents the human ChIP-seq portion of this dataset on leukemia cell lines.
    Mus musculus
    John Rinn | 10/22/2014 - 16:04
    Transcription Profiling (RNA-Seq)
    Illumina HiSeq 2000
    RNA Sequencing of E14.5 mouse cortical neurospheres in response to Fezf2 over-expression. 2 replicates each of GFP-transfected or Fezf2/GFP-transfected E14.5 mouse cortical neurospheres. Paired-end sequencing 101bp.
    Homo sapiens
    John Rinn | 10/27/2014 - 13:18
    Transcription Profiling (RNA-Seq)
    Illumina HiSeq 2500
    We selected primary human myoblasts as a model system of cell differentiation to investigate whether ordering cells by progress revealed new regulators of the process. We sequenced RNA-Seq libraries from each of several hundred cells taken over a time-course of serum-induced differentiation. Please note that this dataset is a single-cell RNA-Seq data set, and each cell comes from a capture plate. Thus, each well of the plate was scored and flagged with several QC criteria prior to library...
    Mus musculus
    Stu Orkin | 11/12/2014 - 11:09
    Transcription Factor Binding (ChIP-Seq)
    Helicos HeliScope Single Molecule Sequencer
    ChIP-seq analyses were performed in MEL cells expressing BirA alone or BirA and FLAG-Biotin tagged BCL11A (XL isoform). BCL11A chromatin occupancy in MEL cell line.
    Homo sapiens
    Stu Orkin | 12/08/2014 - 15:33
    Transcription Factor Binding (ChIP-Seq)
    Illumina HiSeq 2000
    Analysis of genomic occupancy of H3K27me3, H3K27ac, GATA1, TAL1/SCL and GFI1B in primary adult human proerythroblasts by ChIP-seq. We report a computational approach for investigation of chromatin state plasticity. We applied this approach to investigate an ENCODE ChIP-seq dataset profiling the genome-wide distribution of H3K27me3 in 19 human cell lines. We found that high plasticity regions (HPRs) can be divided into two functionally and mechanistically distinct groups, consisting of CpG...
    Homo sapiens
    Sridhar Ramaswamy | 12/09/2014 - 11:14
    Transcription Factor Binding (ChIP-Seq)
    Illumina HiSeq 2000
    Cyclin-dependent kinase 7 (CDK7) plays a critical role in the general regulation of RNA polymerase II-mediated transcription. However, the absence of selective CDK7 inhibitors has hindered the ability to investigate the consequences of acute and prolonged inhibition of CDK7 under normal and pathological conditions. Here we present the discovery and characterization of the first covalent CDK7 inhibitor, CDK7-IN-1, that has the unprecedented ability to target a unique cysteine residue located...
    Homo sapiens
    Sridhar Ramaswamy | 12/09/2014 - 14:36
    Transcription Profiling (Microarray)
    Affymetrix Human Gene Expression Array (with External spike-in RNAs)
    Cyclin-dependent kinase 7 (CDK7) plays a critical role in the general regulation of RNA polymerase II-mediated transcription. However, the absence of selective CDK7 inhibitors has hindered the ability to investigate the consequences of acute and prolonged inhibition of CDK7 under normal and pathological conditions. Here we present the discovery and characterization of the first covalent CDK7 inhibitor, CDK7-IN-1, that has the unprecedented ability to target a unique cysteine residue located...
    Mus musculus
    Christopher A Walsh | 12/09/2014 - 15:20
    Transcription Factor Binding (ChIP-Seq)
    Illumina Genome Analyzer II
    The progression from stem cell to differentiated neuron is associated with extensive chromatin remodeling that controls gene expression, but the mechanisms that connect chromatin to gene expression are not well defined. Here we show that mutation of ZNF335 causes severe human microcephaly ("small brain"), small somatic size, and neonatal death. Germline Znf335 null mutations are embryonically lethal in mice, whereas RNA-interference studies and postmortem human studies show that...

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