Stem Cell Commons

Promoting Discovery and Reproducibility in Stem Cell Research

User Top Menu

Search experiments

Title: 
FoxO transcription factors as mediators of hematopoietic stem cell resistance to oxidative stress
Measurement Type: 
Transcription Profiling (Microarray)
Design Type: 
Perturbation Design
Factors: 
Cell Type/Cell Line, Genetic Characteristics
Summary: 
Study the effect of the deficiency of FoxO1, FoxO3, and FoxO4 in murine bone marrow hematopoietic stem cells and myeloid progenitors on expression of genes involved in reactive oxygen species (ROS) metabolism.
Contact(s): 

Group

Citations: 
FoxOs are critical mediators of hematopoietic stem cell resistance to physiologic oxidative stress.
Tothova Z, Kollipara R, Huntly BJ, Lee BH, Castrillon DH, Cullen DE, McDowell EP, Lazo-Kallanian S, Williams IR, Sears C, et al.
Cell. 2007 Jan 26; 128(2):325-39. PMID: 17254970. Abstract
Download: 
Study metadata (ISA-Tab: isa_7293_694122.zip)