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Title: 
RNA sequencing of circulating tumour cells implicates WNT signaling in pancreatic cancer metastasis (mouse data)
Measurement Type: 
Transcription Profiling (RNA-Seq)
Factors: 
Cell Type/Cell Line, Other (In Sample Notes), Culture Conditions
Summary: 
Expression profiling of primary tumor, circulating tumor cells and ascites in a mouse model of pancreatic cancer suggested WNT signaling plays a role in pancreatic cancer metastasis. Induction of Wnt2 signaling in mouse pancreatic NB508 cells supported the hypothesis.
Contact(s): 
Curator(s): 
mmerrill

Group

Citations: 
RNA sequencing of pancreatic circulating tumour cells implicates WNT signalling in metastasis.
Yu M, Ting DT, Stott SL, Wittner BS, Ozsolak F, Paul S, Ciciliano JC, Smas ME, Winokur D, Gilman AJ, et al.
Nature. 2012 Jul 26; 487(7408):510-3. PMID: 22763454. Abstract
Download: 
Study metadata (ISA-Tab: isa_16061_917105.zip)