Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells.
Myogenic and mesenchymal precursors give rise to soft tissue sarcomas
Transcription Profiling (Microarray)
This work examines sarcoma formation within discrete subsets of KRAS(G12V)-expressing p16p19null myogenic and mesenchymal cells found normally in skeletal muscle. We show that prospectively isolated skeletal muscle precursor cells (SMPs) within the satellite cell pool can serve as cancer cells-of-origin for mouse rhabdomyosarcomas (soft tissue sarcomas with features of myogenic differentiation). Alternatively, non-myogenic progenitors (ScaPCs) induce sarcomas lacking myogenic differentiation markers.
Study metadata (ISA-Tab: isa_13833_845411.zip)