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Title: 
Myogenic and mesenchymal precursors give rise to soft tissue sarcomas
Measurement Type: 
Transcription Profiling (Microarray)
Design Type: 
Perturbation Design
Factors: 
Genetic Characteristics
Summary: 
This work examines sarcoma formation within discrete subsets of KRAS(G12V)-expressing p16p19null myogenic and mesenchymal cells found normally in skeletal muscle. We show that prospectively isolated skeletal muscle precursor cells (SMPs) within the satellite cell pool can serve as cancer cells-of-origin for mouse rhabdomyosarcomas (soft tissue sarcomas with features of myogenic differentiation). Alternatively, non-myogenic progenitors (ScaPCs) induce sarcomas lacking myogenic differentiation markers.
Contact(s): 
Curator(s): 
Sudeshna Das

Group

Citations: 
Sarcomas induced in discrete subsets of prospectively isolated skeletal muscle cells.
Hettmer S, Liu J, Miller CM, Lindsay MC, Sparks CA, Guertin DA, Bronson RT, Langenau DM, Wagers AJ
Proc Natl Acad Sci U S A. 2011 Dec 13; 108(50):20002-7. PMID: 22135462. Abstract
Download: 
Study metadata (ISA-Tab: isa_13833_845411.zip)