Genome wide DNA methylation analysis of leukemia and reprogrammed leukemia cells (sequencing)
DNA Methylation Profiling (Bisulfite-Seq)
Parallel Group Design
Cell Type/Cell Line
We analyzed the methylation pattern of a well characterized leukemia cell line, named K562. Furthermore, we decided to investigate how the malignant epiegenome changes during the reprogramming process. We used RRBS analysis to investigate the methylation pattern in leukemia and reprogrammed leukemia (LiPS) cell lines. We show that the erasure of the epigenetic aberrancies have functional consequences on the leukemia phenotype.
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