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Title: 
Genome wide DNA methylation analysis of leukemia and reprogrammed leukemia cells (sequencing)
Measurement Type: 
DNA Methylation Profiling (Bisulfite-Seq)
Design Type: 
Parallel Group Design
Factors: 
Cell Type/Cell Line
Summary: 
We analyzed the methylation pattern of a well characterized leukemia cell line, named K562. Furthermore, we decided to investigate how the malignant epiegenome changes during the reprogramming process. We used RRBS analysis to investigate the methylation pattern in leukemia and reprogrammed leukemia (LiPS) cell lines. We show that the erasure of the epigenetic aberrancies have functional consequences on the leukemia phenotype.
Contact(s): 
Curator(s): 
Terah Hansen

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