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Montana State University education professor Bryce Hughes' paper, 'Coming Out in STEM: factors affecting retention of sexual minority STEM students,' was published March 14 in Science Advances. Hughes found students who identified as lesbian, gay, bisexual or queer were 7 percent less likely than their heterosexual peers to complete their STEM degree.
A bioengineered retinal implant is safe for use in humans and may be effective in treating vision loss caused by a type of macular degeneration, a progressive blinding disease where no therapeutic options currently exist for advanced stages of the condition.
Age-related macular degeneration (AMD) affects more than 1.75 million individuals in the United States. Because the population is aging, that number will increase to almost 3 million by 2020. Between 80 and 90 percent of cases in this country are the dry version of the condition, for which no effective treatment exists.
Physicians and researchers at the USC Roski Eye Institute have collaborated with other California institutions to show that a first-in-kind stem cell-based retinal implant is feasible for use in people with advanced dry age-related macular degeneration.
Liver stem cells that express high levels of telomerase, a protein often associated with resistance to aging, act in mice to regenerate the organ during normal cellular turnover or tissue damage, according to a study by researchers at the Stanford University School of Medicine.
Researchers have developed a radically new approach to growing in the lab adult-like human heart muscle from human induced pluripotent stem cells in only four weeks. They compressed the development timeframe into a faster, more complete transition to cardiac maturity than any other team has done so far. They formed cardiac tissues from early-stage iPSC-derived cardiomyocytes, soon after the initiation of spontaneous contractions, by subjecting the cells encapsulated in hydrogel to increasingly intense physical conditioning.
Researchers are now able to use induced pluripotent stem cells (iPSC) to form a model of human adult-like cardiac muscle by introducing electric and mechanical stimulation at an early stage.
Cells with stem-cell characteristics appear to be especially important in the formation and metastasis of tumors. Scientists have now developed a universal fluorescent probe for these 'cancer stem cells.' As reported in the journal Angewandte Chemie, this dye also selectively kills off the cells.
Utilizing the humanized mouse model, researchers find that simian immunodeficiency virus, SIV, evolved to infect humans as HIV via Vpu evolving to inhibiting tetherin.
Every day, stem cells in our bone marrow produce billions of new red blood cells. Any disruption in this process can result in serious disease. Researchers from Charité - Universitätsmedizin Berlin and Harvard Medical School have succeeded in furthering our understanding of how blood cells are formed. Their insights into the molecular foundations of this process may help break new ground in the treatment of certain types of anemia. The results of this study have been published in Cell.
Mouse genes that make human T cells powerful at fighting liver cancer could one day help patients do the same, scientists report. Georgia Cancer Center scientists exposed mice genetically manipulated to respond to human antigens to a common antigen found in human liver cancer.
UCLA researchers have come up with a computational tool that increases the reliability of measuring how strongly genes are expressed in an individual cell.
A research team has demonstrated that cell sex considerably influenced cellular uptake of nanoparticles and found that cells from men and women responded differently to reprogramming techniques used to enhance the ability of the cells to differentiate into a greater variety of cell types.
In a step toward accelerating the production of new gene therapies, scientists report in ACS Nano that they have developed remote-controlled, needle-like nanospears capable of piercing membrane walls and delivering DNA into selected cells. They say the new technique, which can ferry biological materials to cells with pinpoint accuracy, overcomes many of the existing barriers to effective gene modification.
Researchers have fused living and non-living cells for the first time in a way that allows them to work together, paving the way for new applications.
Sexual minority students -- lesbian, gay, bisexual and queer -- were less likely than their heterosexual peers to be retained in STEM degrees after four years of college, suggests a new study based on a national survey of more than 4,000 college students. Diversity is crucial in STEM fields, providing a greater likelihood of reaching breakthroughs. However, compared.
Researchers at the University of Pennsylvania set out to determine whether and how gum-derived stem cells play a role in accelerated wound healing. Their results, indicating that these cells secrete tiny vesicles packed with signaling proteins, point the way forward for therapeutic strategies that aim to harness the prowess of stem cells to treat delayed wound healing as well as other conditions that involve an overactive inflammatory response, such as autoimmune diseases.
Whether caused by an undetected birth defect or by a heart attack (myocardial infarction), when a heart sustains damage, it can be difficult to repair.
Stem cell therapy is acknowledged as having great potential for the treatment of a variety of diseases in both people and animals. The use of bone marrow-derived stem cells is well established in the treatment of human cancer patients, and veterinary applications for bone marrow- and adipose-derived stem cells are being evaluated
These findings led them to hypothesize that antibodies generated against the C-terminus Shh epitope can bind and neutralize full-length Shh found exclusively on the CSC population, while leaving the cleaved N-terminus Shh, important for physiologic Shh signaling, unperturbed.