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A new study in patients with the inherited metabolic disorder methylmalonic academia (MMA) found lower than expected levels of antibodies against the adeno-associated viral (AAV) vectors being developed for gene therapy to replace the enzyme (MUT) that is deficient in MMA. (2016-04-06)
An experimental antibody treatment decreased by half the number of cancer stem cells that drive the growth of tumors in nearly all patients with multiple myeloma, a cancer of the bone marrow and bone tissue, according to results of a preliminary clinical trial led by Johns Hopkins Kimmel Cancer Center scientists. (2016-04-18)
After a stroke, there is inflammation in the damaged part of the brain. (2016-04-18)
Cancer patients who receive a particular type of chemotherapy called doxorubicin run a risk of sustaining severe, lasting heart damage. But it is not possible to predict who is likely to experience this serious side effect. It is also unknown exactly how the drug damages heart muscle. (2016-04-19)
Two existing chemotherapy drugs appear to be a powerful pair in targeting errant stem cells that are making breast cancer and enabling its spread and recurrence, scientists report. (2016-05-03)
The most productive way scientists have devised to nurture colonies of human embryonic stem cells is to do so atop a bed of mouse cells. (2016-05-03)
An innovative mechanical system that mimics the ventilation and blood flow in the chest cavity, housed in a specialized, sterile bioreactor, can support the growth of engineered whole lungs at human scale. (2016-05-04)
With only three living individuals left on this planet, the northern white rhinoceros could be considered doomed for extinction. (2016-05-04)
In the late 1980s and over the 1990s, researchers at Lund University in Sweden pioneered the transplantation of new nerve cells into the brains of patients with Parkinson's disease. (2016-05-04)
In December 2015 an international group of scientists convened in Austria to discuss the imminent extinction of the northern white rhinoceros and the possibility of bringing the species back from brink of extinction. (2016-05-04)
The U.S. Centers for Disease Control and Prevention recently concluded that Zika virus infection in pregnant women can stunt neonatal brain development, leading to babies born with abnormally small heads, a condition known as microcephaly. (2016-05-09)
A new addition in the growing number of studies using brain organoids to understand how the Zika virus leads to microcephaly reveals that human neural stem cells infected by the virus subsequently trigger an innate immune response that leads to cell death. (2016-05-09)
Promising results from the first clinical trials of globin gene transfer to treat beta-thalassemias-inherited forms of anemia-have eliminated the need for blood transfusions in some individuals. (2016-05-09)
A new study shows that the anti-tumor effect of oncolytic virus therapy is significantly greater in mice when the virus is genetically modified to express a junction opening (JO) protein, which helps the cancer-killing agent better penetrate solid tumors. (2016-05-10)
Two patients with melanoma that had spread to the liver survived for at least 8.5 and 12 years after resection of the hepatic tumor and treatment with patient-specific immunotherapeutic vaccines. (2016-05-11)
Signaling a potential new approach to treating diabetes, researchers at Washington University School of Medicine in St. Louis and Harvard University have produced insulin-secreting cells from stem cells derived from patients with type 1 diabetes. (2016-05-11)
Researchers at University of California San Diego School of Medicine, with colleagues in Brazil and Senegal, have described the first "direct experimental proof" that the Brazilian strain of Zika virus can actually cause severe birth defects. (2016-05-12)
Scientists at the University of Sheffield have identified a protein, involved in the development of the human placenta, may also help embryos implant in the womb - something which could improve treatments for recurrent miscarriages and pre-eclampsia. (2016-05-13)
A growing body of research is revealing associations between birth defects and a father's age, alcohol use and environmental factors, say researchers at Georgetown University Medical Center. They say these defects result from epigenetic alterations that can potentially affect multiple generations. (2016-05-16)
Transplanting a preformed dense and coherent sheet of regenerative stem cells directly onto damaged heart, cartilage or bone tissue of ailing patients often is a more promising route to recovery than transplanting the cells just loosely mixed together. (2016-05-18)